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Cell Types

Lymphoid Tissue inducer cells

Lymphoid Tissue inducer cells (LTi) are involved in the induction and function of lymphoid tissues.  Feotal LTi cells are essential for the development of lymph node anlagen.  Adult LTi cells have roles in regulating T cell function in immune respsonses.

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Fibroblastic Reticular Cells

Fibroblastic Reticular Cells (FRCs) are specialized stromal cell found in the T cell zone.  An alternative name for the cells are T cell zone Reticular Cells (TRCs).  They are characterised by the expression of CCL19, CCL21, Smooth Muscle Actin, Desmin.

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Follicular Dendritic Cells

Follicular Dendritic Cells (FDCs) are specialized stromal cell found in the B cell follicles.  They are characterised by the expression of CXCL13, Complement Receptor and high levels of Prion Protein.

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Marginal Reticular Cells

Marginal Reticular Cells (MRCs) are specialized stromal cell found in the subcapsular zone of the lymph node.  They are characterised by the expression of RANK-Ligand, VCAM-1, ICAM-1.

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Follicular Stromal Cells

Folluicular Stromal Cells (FSCs) are a specialized stromal cell that support B cells.  Relatively little is known about these cells however they are thought to be precursor cells to Follicular Dendritic Cells.

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Stromal Cell – Immune Cell interactions

Stroma: There are four types of stromal cells detailed, Fibroblastic Recticular Cells (FRCs) (or T cell zone Reticular Cells (TRCs)), Marginal Reticular Cells (MRCs), Follicular Dendritic Cells (FDCs) and Follicular Stromal Cells (FSCs) (or B cell stroma).

Tissue Inducing cells: There are two types of tissue inducing cells Lymphoid Tissue inducing cells (LTi cells) and Lymphoid Tissue initiating cells (LTin cells).

Lymphoid Cells: T lymphocytes (T cells), B lymphocytes (B cells) and Natural Killer (NK) Cellls invovled in lymphoid tissue formation.  Stromal cells regulate lymphiod cell function.

Other Innate Cells: Dendritic Cells (DCs) and Macrophages (Mac) function is regulated by stromal cells… Full article >

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